Panel A: Individual levels of LTB
in supernatants of alveolar macrophages before and after lipopolysaccharide (LPS) from normal subjects (n = 9), non-severe asthmatics (n = 9) and severe asthmatics (n = 8). In the asthmatic groups, closed symbols indicate those on regular treatment with inhaled and/or oral corticosteroids. Panel B: Mean levels of LPS-stimulated LTB4 represented by the difference between LTB4 levels with LPS and the basal level of LTB4 in the 3 groups. Data shown as mean ± SEM.