Figure 8

Effect of miR-146a inhibitors and mimics upon IL-1β-induced proliferation and cell number. HASM cells were exposed to either vehicle control, the indicated FCS concentration or the indicated concentration of IL-1β for 48 h, 72 h or 96 h before measurement of proliferation (A) or cell number (B). In panel C, HASM cells were electroporated in the presence of buffer, control inhibitor or miR-146a inhibitor, control mimic or miR-146a mimic. Cells were then exposed to vehicle control or 1 ng/ml IL-1β and proliferation and cell number was measured at 48 h. These results are mean ± SEM of three independent experiments.