Expression of CXCL-8 (A) and TNF-α (B) in supernatant of human lung tissue after
infection with NTHI-1 and NTHI-2. Signals are indicated by arrows. Expression of pp38 in human lung tissue (C: IHC, 400×; D: Western Blot). TGF-β expression in supernatant of in vitro infected human lung tissue with NTHI-1 and NTHI-2 (E) and A549 cells (F). IHC of TGF-β in human lung tissue without (G, 400×) and with (H, 400×) NTHI-1 in vitro infection. SB (203580) = p38 MAPK inhibitor; IHC = Immunohistochemistry, NTHI-1, n = 6; NTHI-2, n = 5; * = p < 0.01, + = p < 0.05.