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Table 3 Protective effects of study treatments in repeated AMP provocations

From: Protective effect of budesonide/formoterol compared with formoterol, salbutamol and placebo on repeated provocations with inhaled AMP in patients with asthma: a randomised, double-blind, cross-over study

 

Fall in FEV1 in AMP provocation at 3 hours (%)

Fall in FEV1 in AMP provocation at 7 hours (%)

AUC0-60-FEV1 in AMP provocation at 7 hours (h.%)

Budesonide/formoterol

8.8 (4.0, 13.6)

15.7 (10.7, 20.8)

-4.2 (- 8.6, 0.2)

Formoterol

17.0 (11.8, 22.1)*

20.1 (14.6, 25.5)

-10.7 (- 15.4, -6.0)*

Salbutamol

20.1 (15.0, 25.2)#

29.8 (24.4, 35.2)$

-17.9 (- 22.5, -13.2)$

Placebo

27.1 (22.3, 31.8)$

31.9 (26.9, 36.9)$

-19.9 (- 24.3, -15.6)$

  1. Data shown as Least Square Mean and 95% Confidence Interval; FEV1: forced expiratory volume in 1 second; AMP: adenosine 5'-monophoshate; fall in FEV1 as % from baseline prior to each AMP provocation; AUC0-60: Area Under the Curve for % change in FEV1 from 0 to 60 minutes after AMP provocation; p-values from ANOVA, differences compared with budesonide/formoterol: *p < 0.05, #p < 0.01, $p < 0.001.