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Figure 9 | Respiratory Research

Figure 9

From: K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport

Figure 9

Verapamil regulates heterologously expressed human αβγ ENaC in oocytes in a Ca2+-dependent pattern. (A & B) Time-courses of whole-cell current traces at -100 mV recorded in oocytes perfused with verapamil under normal (A) and Ca2+-chelated conditions (B). 10 μM amiloride were added at the end of recording to compute basal and verapamil-inhibitable ASI levels. (C & D) Effects of verapamil on ENaC activity in control (C) and Ca2+-chelated (D) oocytes. The shift of base line in Ca2+-chelated cells (B) was corrected for comparing the current levels before (Basal) and after verapamil (Verapamil). Paired t-test. *P < 0.05.

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