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Figure 3 | Respiratory Research

Figure 3

From: K+ channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport

Figure 3

Effects of CCB compounds on transepithelial short-circuit currents (Isc) in intact H441 monolayers. (A-C) Typical traces. 200 μM nifedipine (A), 10 μM bepridil (B) or 50 μM diltiazem (C) was added to the basolateral compartment followed by verapamil. Amiloride (100 μM, apical side) was finally applied to inhibit residual amiloride-sensitive currents. Arrows show the time point of addition. Total AS Isc is the difference between the Isc level before CCB and the amiloride-insensitive fraction, as indicated by a pair of vertical arrows. (D) CCB-sensitive fraction: CCB-inhibitable Isc/total AS Isc. One-way ANOVA. *P < 0.05 vs Verapamil. n = 3-10.

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