Skip to main content

Table 5 Comparison of systemic biomarkers by severity of COPD according to quartiles of BODE index*.

From: Systemic inflammation in chronic obstructive pulmonary disease: a population-based study

  Quartile 1
(n = 282)
Quartile 2
(n = 19)
Quartiles 3-4
(n = 12)
p
Male (%) 73.8 84.2 58.3 0.279
Age (yr) 60 (55-71) 72 (69-75) † 66 (61-72) 0.007
BMI (Kg/m2) 27.7 (4.3) 29.9 (8.0) 31.1 (8.2) † 0.011
Smoking status     0.303
   Never smoker 38.3 31.6 16.7  
   Former smoker 41.1 57.9 50.0  
   Current smoker 20.6 10.5 33.3  
Smoking exposure (packs-year) 40 (25-50) 50 (23-85) 50 (32-59) 0.050
C-reactive protein (mg/dl) 3.0 (2.0-5.0) 3.0 (2.0-6.0) 4.5 (2.0-24.7) ठ0.0001
TNF-alpha (pg/ml) 10.0 (7.0-14.5) 11.0 (8.5-16.0) 12.0 (7.7-15.0) 0.992
IL-6 (pg/ml) 1.9 (1.9-4.0) 3.0 (1.9-12.0) 2.5 (1.9-12.0) 0.032
IL-8 (pg/ml) 2.0 (0.7-8.0) 7.0 (4.0-13.0) 10.5 (0.7-25.2) † 0.004
Alpha-1 antitrypsin (g/l) 1.46 (1.29-1.69) 1.56 (1.24-1.72) 1.69 (1.56-1.84) 0.444
Fibrinogen (g/l) 3.54 (1.06) 3.66 (1.29) 3.93 (1.14) 0.446
Albumin (g/l) 45.39 (2.73) 44.06 (3.49) 45.75 (2.34) 0.122
Nitrites/nitrates (nmol/l) 24.9 (19.7-34.2) 29.5 (20.1-35.4) 22.4 (16.4-83.2) † 0.030
  1. * Values are mean (SD) or median (interquartile range) depending on the distribution. Abbreviations: TNF = tumour necrosis factor; IL = interleukin. Comparisons between groups by ANOVA with Bonferroni test: † p < 0.05 vs. quartile 1, ‡ p < 0.01 vs. quartile 1; § p < 0.01 vs. quartile 2.