From: Systemic inflammation in chronic obstructive pulmonary disease: a population-based study
Quartile 1 (n = 282) | Quartile 2 (n = 19) | Quartiles 3-4 (n = 12) | p | |
---|---|---|---|---|
Male (%) | 73.8 | 84.2 | 58.3 | 0.279 |
Age (yr) | 60 (55-71) | 72 (69-75) † | 66 (61-72) | 0.007 |
BMI (Kg/m2) | 27.7 (4.3) | 29.9 (8.0) | 31.1 (8.2) † | 0.011 |
Smoking status | 0.303 | |||
Never smoker | 38.3 | 31.6 | 16.7 | |
Former smoker | 41.1 | 57.9 | 50.0 | |
Current smoker | 20.6 | 10.5 | 33.3 | |
Smoking exposure (packs-year) | 40 (25-50) | 50 (23-85) | 50 (32-59) | 0.050 |
C-reactive protein (mg/dl) | 3.0 (2.0-5.0) | 3.0 (2.0-6.0) | 4.5 (2.0-24.7) ‡§ | 0.0001 |
TNF-alpha (pg/ml) | 10.0 (7.0-14.5) | 11.0 (8.5-16.0) | 12.0 (7.7-15.0) | 0.992 |
IL-6 (pg/ml) | 1.9 (1.9-4.0) | 3.0 (1.9-12.0) | 2.5 (1.9-12.0) | 0.032 |
IL-8 (pg/ml) | 2.0 (0.7-8.0) | 7.0 (4.0-13.0) | 10.5 (0.7-25.2) † | 0.004 |
Alpha-1 antitrypsin (g/l) | 1.46 (1.29-1.69) | 1.56 (1.24-1.72) | 1.69 (1.56-1.84) | 0.444 |
Fibrinogen (g/l) | 3.54 (1.06) | 3.66 (1.29) | 3.93 (1.14) | 0.446 |
Albumin (g/l) | 45.39 (2.73) | 44.06 (3.49) | 45.75 (2.34) | 0.122 |
Nitrites/nitrates (nmol/l) | 24.9 (19.7-34.2) | 29.5 (20.1-35.4) | 22.4 (16.4-83.2) † | 0.030 |