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Table 3 Significance of each multivariate model to estimate systemic biomarkers*.

From: Systemic inflammation in chronic obstructive pulmonary disease: a population-based study

Biomarker Parameter Coefficient (SE) Wald 95% CI p-value
C-reactive protein† Intercept -0.44 (0.173) -0.785- -0.103 0.011
  Age 0.005 (0.002) 0.001-0.009 0.012
  BMI 0.019 (0.004) 0.011-0.028 0.001
  Smoker 0.036 (0.155) -0.268-0.340 0.816
  Gender -0.004 (0.044) -0.089-0.083 0.936
  COPD group 0.101 (0.049) 0.004-0.198 0.041
TNF-alpha Intercept 6.306 (4.301) -2.151-14.763 0.143
  Age 0.062 (0.049) -0.034-0.158 0.207
  BMI 0.059 (0.110) -0.157-0.276 0.590
  Smoker 0.810 (3.434) -5.942-7.562 0.814
  Gender -0.989 (1.088) -3.128-1.150 0.364
  COPD group 2.668 (1.250) 0.211-5.125 0.033
IL-6 Intercept 3.420 (2.477) -1.450-8.290 0.168
  Age 0.025 (0.028) -0.030-0.081 0.367
  BMI 0.017 (0.063) -0.108-0.142 0.787
  Smoker -0.597 (1.934) -4.399-3.204 0.758
  Gender -1.525 (0.619) -2.741- -0.309 0.014
  COPD group 1.194 (0.713) -0.207-2.595 0.095
IL-8 Intercept 9.436 (4.712) 0.173-18.700 0.046
  Age -0.007 (0.053) -0.112-0.098 0.892
  BMI -0.214 (0.121) -0.451-0.024 0.078
  Smoker 2.951 (3.672) -4.267-10.169 0.422
  Gender 0.277 (1.175) -2.034-2.587 0.814
  COPD group 3.995 (1.350) 1.342-6.648 0.003
Alpha-1 antitrypsin Intercept 1.307 (0.184) 0.947-1.668 < 0.001
  Age 0.003 (0.002) -0.001-0.007 0.153
  BMI 0.001 (0.005) -0.011-0.008 0.785
  Smoker 0.069 (0.143) -0.351-0.213 0.630
  Gender 0.003 (0.046) -0.087-0.093 0.945
  COPD group 0.084 (0.053) -0.019-0.187 0.112
Fibrinogen Intercept 0.484 (0.416) -0.335-1.302 0.246
  Age 0.030 (0.005) 0.020-0.039 0.001
  BMI 0.021 (0.011) 0.000-0.042 0.050
  Smoker -0.087 (0.325) -0.726-0.551 0.788
  Gender 0.344 (0.104) 0.139-0.549 0.001
  COPD group 0.134 (0.119) -0.100-0.369 0.260
Albumin Intercept 50.071 (1.165) 47.781-52.361 0.001
  Age -0.066 (0.013) -0.092- -0.040 0.001
  BMI 0.028 (0.030) -0.031-0.087 0.350
  Smoker -0.083 (0.911) -1.873-1.707 0.928
  Gender -0.759 (0.290) -1.329- -0.188 0.009
  COPD group -0.299 (0.333) -0.955-0.356 0.370
Nitrites/nitrates† Intercept 1.636 (0.097) 1.445-1.828 0.001
  Age -0.001 (0.001) -0.003-0.001 0.35
  BMI -0.004 (0.002) -0.009-0.000 0.116
  Smoker -0.007 (0.076) -0.157-0.143 0.926
  Gender -0.079 (0.024) -0.127- -0.031 0.001
  COPD group 0.059 (0.028) 0.004-0.114 0.034
  1. * Main effects of factors and covariates included in the generalized linear model analysis. Smoker was defined as current or former smoker of > 10 packs-year (yes/no). COPD group effect was estimated versus reference group. † Parameter with logarithmic transformation.