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Table 3 Significance of each multivariate model to estimate systemic biomarkers*.

From: Systemic inflammation in chronic obstructive pulmonary disease: a population-based study

Biomarker

Parameter

Coefficient (SE)

Wald 95% CI

p-value

C-reactive protein†

Intercept

-0.44 (0.173)

-0.785- -0.103

0.011

 

Age

0.005 (0.002)

0.001-0.009

0.012

 

BMI

0.019 (0.004)

0.011-0.028

0.001

 

Smoker

0.036 (0.155)

-0.268-0.340

0.816

 

Gender

-0.004 (0.044)

-0.089-0.083

0.936

 

COPD group

0.101 (0.049)

0.004-0.198

0.041

TNF-alpha

Intercept

6.306 (4.301)

-2.151-14.763

0.143

 

Age

0.062 (0.049)

-0.034-0.158

0.207

 

BMI

0.059 (0.110)

-0.157-0.276

0.590

 

Smoker

0.810 (3.434)

-5.942-7.562

0.814

 

Gender

-0.989 (1.088)

-3.128-1.150

0.364

 

COPD group

2.668 (1.250)

0.211-5.125

0.033

IL-6

Intercept

3.420 (2.477)

-1.450-8.290

0.168

 

Age

0.025 (0.028)

-0.030-0.081

0.367

 

BMI

0.017 (0.063)

-0.108-0.142

0.787

 

Smoker

-0.597 (1.934)

-4.399-3.204

0.758

 

Gender

-1.525 (0.619)

-2.741- -0.309

0.014

 

COPD group

1.194 (0.713)

-0.207-2.595

0.095

IL-8

Intercept

9.436 (4.712)

0.173-18.700

0.046

 

Age

-0.007 (0.053)

-0.112-0.098

0.892

 

BMI

-0.214 (0.121)

-0.451-0.024

0.078

 

Smoker

2.951 (3.672)

-4.267-10.169

0.422

 

Gender

0.277 (1.175)

-2.034-2.587

0.814

 

COPD group

3.995 (1.350)

1.342-6.648

0.003

Alpha-1 antitrypsin

Intercept

1.307 (0.184)

0.947-1.668

< 0.001

 

Age

0.003 (0.002)

-0.001-0.007

0.153

 

BMI

0.001 (0.005)

-0.011-0.008

0.785

 

Smoker

0.069 (0.143)

-0.351-0.213

0.630

 

Gender

0.003 (0.046)

-0.087-0.093

0.945

 

COPD group

0.084 (0.053)

-0.019-0.187

0.112

Fibrinogen

Intercept

0.484 (0.416)

-0.335-1.302

0.246

 

Age

0.030 (0.005)

0.020-0.039

0.001

 

BMI

0.021 (0.011)

0.000-0.042

0.050

 

Smoker

-0.087 (0.325)

-0.726-0.551

0.788

 

Gender

0.344 (0.104)

0.139-0.549

0.001

 

COPD group

0.134 (0.119)

-0.100-0.369

0.260

Albumin

Intercept

50.071 (1.165)

47.781-52.361

0.001

 

Age

-0.066 (0.013)

-0.092- -0.040

0.001

 

BMI

0.028 (0.030)

-0.031-0.087

0.350

 

Smoker

-0.083 (0.911)

-1.873-1.707

0.928

 

Gender

-0.759 (0.290)

-1.329- -0.188

0.009

 

COPD group

-0.299 (0.333)

-0.955-0.356

0.370

Nitrites/nitrates†

Intercept

1.636 (0.097)

1.445-1.828

0.001

 

Age

-0.001 (0.001)

-0.003-0.001

0.35

 

BMI

-0.004 (0.002)

-0.009-0.000

0.116

 

Smoker

-0.007 (0.076)

-0.157-0.143

0.926

 

Gender

-0.079 (0.024)

-0.127- -0.031

0.001

 

COPD group

0.059 (0.028)

0.004-0.114

0.034

  1. * Main effects of factors and covariates included in the generalized linear model analysis. Smoker was defined as current or former smoker of > 10 packs-year (yes/no). COPD group effect was estimated versus reference group. † Parameter with logarithmic transformation.