Mucosal sensitization to German cockroach involves protease-activated receptor-2

Respiratory Research

Table 2 Differential cell count in BAL fluid of wild type and PAR-2-deficient mice.

	Mac	Epi	Eos	Neut	Lymph
Balb/c-PBS	0.9 ± 0.4	1.8 ± 0.6	0	0.04 ± 0.02	0.07 ± 0.06
PAR2-/- PBS	2.0 ± 0.7	3.0 ± 1.2	0	0.02 ± 0.02	0.04 ± 0.02
Balb/c-frass	7.8 ± 0.9*	5.2 ± 1.1	4.7 ± 1.3*	5.9 ± 3.9*	2.9 ± 0.7*
PAR2-/- frass	3.8 ± 0.9**	3.1 ± 1.2	1.7 ± 0.8**	0.8 ± 0.2**	2.3 ± 0.9*

Wild type (Balb/c) or PAR-2-deficient mice were given intratracheal inhalations of PBS (40 μl) or GC frass (40 μg/40 μl) on days 0, 7, and 14. On day 17, BAL fluid was harvested and differential cell counts performed. These data represent 4 mice per group and are expressed as mean ± SEM of cell number × 10⁴. Cell counts were statistical significance between GC frass and PBS exposed mice (*p < 0.05, as determined by ANOVA). In addition, statistical differences were found between Balb/c and PAR-2-deficient mice exposed to GC frass (**p < 0.05).

ISSN: 1465-993X