Figure 9

In vivomodulation of cholesterol in CF and wt mice with resveratrol. Membrane cholesterol measurement in Cftr -/- mouse (A) nasal epithelium and in Cftr +/+ mouse (B) nasal epithelium in response to in vivo exposure to resveratrol (drug treated, RES) (15-28 mg/kg body weight) for 3 to 6 weeks. Representative tracings of electrochemical detection of membrane cholesterol are shown. Shown are three separate tracings (separate electrodes) from tissue from a single mouse. C) Tissues from three treated and three untreated Cftr -/- mice were examined by eight separate electrodes and means represented in bar graph. Tissues from three treated and three untreated Cftr +/+ mice were examined by six separate electrodes and means represented in bar graph *Significance determined from n = 3, p-value < 0.05 as determined by t-test.