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Table 2 PFC effects on cells and cellular membranes

From: Effects of Perfluorocarbons on surfactant exocytosis and membrane properties in isolated alveolar type II cells

 

PFD

PP2

Rate of FM 1-43 uptake

124 ± 17%*

121 ± 7%*

Total FM 1-43 uptake

128 ± 10%*

123 ± 14%*

Total LY uptake

94 ± 15%

105 ± 16%

Trypan Blue

101 ± 6%

106 ± 6%

DPH fluorescence anisotropy

0.105 ± 0.03

0.102 ± 0.03

  1. Effects of PFC after 6 hours incubation on permeability properties (rate and total uptake of FM 1-43), endocytosis (total LY uptake), vitality (Trypan Blue) and membrane fluidity (DPH fluorescence anisotropy). Shown are relative data, mean and standard deviation, of PFC incubated ATII cells vs. cells without PFC incubation (= 100%; n = 3 independent rat preparations with 5 samples each; *p < 0.05). Anisotropy measurements were performed with A549 cells and presented are absolute data (r ss untreated control cells = 0.119 ± 0.03; [24].