Table 3 Inflammatory cells and soluble mediators in induced sputum after either air or ozone exposure, in subjects grouped according to functional response to ozone exposure
Responders (n = 8) | Nonresponders (n = 13) | |||
|---|---|---|---|---|
Air | Ozone | Air | Ozone | |
Infamm. cells/ml (106) | 2.6(1.5-5.7) | 3.6(1.2-10.8) | 2.1(0.2-6.8) | 3.1(0.7-14.0) |
Macrophages/ml (106) | 0.9(0.3-2.2) | 1.4(0.3-3.2) | 0.8(0.1-2.5) | 0.9(0.4-10) |
Lymphocytes/ml (106) | 0.03(0-0.3) | 0.09(0-0.4) | 0.02(0-0.1) | 0.02(0-0.1) |
Neutrophils/ml (106) | 0.7(0.2-2.0) | 1.7(0.5-9.2)§ | 0.6(0-6.3) | 0.8(0.1-7.0) |
Eosinophils/ml (106) | 0.09(1-1.9) | 0.02(0-0.6) | 0.02(0-1.7) | 0.4(0-1.6) #§ |
Macrophages (%) | 40.4(8-89) | 34.3(8-77) | 51.1(6-85) | 48.2(2-75) |
Lymphocytes (%) | 1.5(1-6) | 1.4(0-14) | 0.6(0-5) | 0.8(0-5) |
Neutrophils (%) | 28.2(8-79) | 55.4(23-90)§ | 41.0(0-93) | 30.9(6-98) |
Eosinophils (%) | 2.8(0-55) | 0.2(0-11) | 0.3(0-63) | 11.6(0-45)#§ |
NE (ng/mL) | 0.7(0-6) | 2.1(0-9) | 1.2(0-5) | 1.5(0-6.5) |
NE rec.(%) | 42(1-61) | 59(34-83) | 41(9-62) | 60(33-78) ^ |
IL-8 (ng/mL) | 22.9(10-44) | 36.3(3-62) | 11.8(6-72) | 26.3(3-94) § |