Clinical patterns in asthma based on proximal and distal airway nitric oxide categories

Respiratory Research

Table 2 Clinical patterns of the eNO categories

	Type I Normal Nitric Oxide	Type II Proximal Airway Predominant	Type III Proximal and Distal Airway Predominant	Type IV Distal Airway Predominant
EXHALED NITRIC OXIDE
J'aw_NO (nl/s)	< 1.5	≥ 1.5	≥ 1.5	< 1.5
CA_NO (ppb)	< 2.3	< 2.3	≥ 2.3	≥ 2.3
FE_NO,50 (ppb)^#	▪	▪▪▪▪	▪▪▪▪	▪
THERAPY AND ATOPY
Atopy	▪▪▪	▪▪▪▪	▪▪▪▪	▪▪▪
ICS treatment	▪▪▪▪	▪▪▪	▪	▪▪▪▪
LUNG FUNCTION
Abnormal Spirometry	▪	▪	▪	▪
BDR > 10%	▪	▪▪	▪▪▪	▪
CONTROL and RISK
ACT ≤ 19	▪	▪	▪▪▪▪	▪▪▪▪
Morbidity*	▪	▪	▪▪	▪▪

Proportion of subjects: ▪▪▪▪ ≥ 75%, ▪▪▪ 50-74.9%, ▪▪, 25-49.9%; ▪ <25%.
^#Abnormal FE_NO,50 is based on the upper limit of the non-asthmatic, non-atopic controls (≥ 16 ppb).
Abnormal spirometry: FEV₁ % predicted < 80% or FVC % predicted < 80% or FEV₁/FVC < 80%.
Asthma control test (ACT) ≤ 19 is indicative of poor asthma control.
* Proportion of subjects with at least one event in the past 8 weeks including visits to the emergency department, severe attacks, and hospitalizations.

ISSN: 1465-993X