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Table 2 Fetal body weights (kg), organ weights (g/kg) and lung volumes (cm3/kg) for fetuses in PPE treatment groups compared to corresponding age-matched control group (* p < 0.05).

From: Partial pulmonary embolization disrupts alveolarization in fetal sheep

 

Study 1

Study 2

 

Age-matched control,

130d GA

1d PPE + 15d,

130d GA

5d PPE + 16d,

130d GA

Age-matched

control,

116d GA

5d PPE, 116d GA

Body wt

(kg)

3.4 ± 0.1

3.2 ± 0.3

3.5 ± 0.2

2.5 ± 0.4

2.3 ± 0.2

Wet lung wt/Body wt

(g/kg)

33.2 ± 1.7

33.8 ± 2.1

31.2 ± 2.8

39.4 ± 5.4

34.3 ± 3.6

Heart wt/Body wt

(g/kg)

7.4 ± 0.2

6.6 ± 0.1*

6.9 ± 0.3

6.3 ± 0.3

7.6 ± 0.2*

Liver wt/Body wt

(g/kg)

27.3 ± 1.4

24.5 ± 2.2

30.2 ± 2.3

27.9 ± 3.7

38.9 ± 2.3

Left Kidney wt/Body wt

(g/kg)

3.1 ± 0.1

2.9 ± 0.1

3.4 ± 0.1

3.7 ± 0.2

4.0 ± 0.2

Right Kidney wt/Body wt (g/kg)

3.1 ± 0.2

2.8 ± 0.2

3.3 ± 0.1

3.8 ± 0.2

3.9 ± 0.2

Total Lung Volume/Body wt (cm3/kg)

27.3 ± 1.7

29.2 ± 2.9

26.8 ± 3.0

N.D.

N.D.

Left Lung Volume/Body wt (cm3/kg)

10.5 ± 0.7

10.4 ± 0.7

11.0 ± 1.1

N.D.

N.D.

Right Lung Volume/Body wt (cm3/kg)

16.7 ± 1.0

18.8 ± 2.3

15.7 ± 2.0

N.D.

N.D.

  1. (ND = not determined)