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Table 6 Within-subject and between-subject coefficients of variation, analytical variation, reference change value in COPD induced sputum samples:

From: Multi analyte profiling and variability of inflammatory markers in blood and induced sputum in patients with stable COPD

Sputum Protein

Within-subject CV (%) (90% CI)

Between-subject CV (%) (90% CI)

Analytical variation (%)

Reference change value (%)

Eotaxin2

70 (53 - 95)

88 (50 - 104)

12.1

196.77

HGF

58 (44 - 76)

66 (46 - 79)

14.3

165.47

IP-10

62 (45 - 82)

54 (32 - 73)

12.2

175.03

KGF

49 (33 - 70)

90 (58 - 126)

8.3

137.66

MMP-13

54 (36 - 72)

69 (43 - 89)

11.0

152.65

TNF-RI

46 (36 - 54)

56 (40 - 65)

8.8

129.73

GROα

78 (56 - 100)

89 (52 - 106)

8.2

217.25

TIMP2

81 (57- 101)

57 (38 - 77)

8.4

225.57

TNF-RII

69 (49 - 89)

104 (65 - 126)

8.6

192.61

α2 macroglobulin

57 (33 - 75)

70 (47 - 84)

6.43

158.89

ENA-78

61 (49 - 74)

88 (60 - 104)

4.32

169.39

IL-13

30 (23 - 37)

101 (32 - 116)

3.25

83.59

IL-15

62 (48 - 76)

121 (64- 149)

3.96

172.09

IL-18

55 (43 - 66)

63 (32 - 73)

3.46

152.65

IL-1β

61 (44 - 77)

160 (113 - 210)

4.58

169.45

IL-1RA

58 (46 - 69)

55 (37 - 68)

5.86

161.48

IL-6

50 (36 - 68)

99 (59 - 118)

3.73

138.88

IL-8

60 (47 - 82)

88 (70 - 106)

3.83

166.54

MCP-1

86 (70 - 99)

146 (84 - 182)

3.95

238.47

MMP-2

57 (39 - 81)

70 (38 - 82)

3.33

158.16

TIMP-1

54 (33- 73)

38 (27 - 46)

5.89

150.47

VEGF

42 (32 - 55)

24 (15 - 31)

4.98

117.15

Median coefficient of variation for all proteins

58

79

5.88

163.47