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Table 3 Within-subject and between-subject coefficients of variation, analytical variation and reference change value in COPD serum samples:

From: Multi analyte profiling and variability of inflammatory markers in blood and induced sputum in patients with stable COPD

Serum Protein

Within-subject CV (%) (90% CI)

Between-subject CV (%) (90% CI)

Analytical variation (%)

Reference change value (%)

Eotaxin2

64 (55 - 77)

65 (50 - 77)

12.1

180.42

IP-10

49 (44 - 57)

62 (50 - 67)

12.2

139.87

TNF-R1

26 (20 - 33)

20 (13 - 29)

8.8

76.03

TNF-RII

50 (42 - 59)

59 (40 - 68)

8.6

140.53

TIMP-2

21 (17 - 26)

20 (13 - 24)

8.4

62.65

HGF

71 (59 - 84)

56 (37 - 65)

14.3

200.62

KGF

55 (46 - 62)

46 (35 - 57)

8.3

154.08

MMP-13

88 (74 - 103)

151 (57 - 172)

11.0

245.66

GROα

32 (26 - 37)

48 (28 - 56)

8.2

91.50

CRP

53 (40 - 69)

94 (67 - 122)

6.05

147.76

ENA-78

16 (13 - 19)

101 (31 - 120)

4.32

45.91

IL-13

19 (18 - 23)

26 (19 - 30)

3.25

53.39

IL-18

21 (17 - 23)

46 (31 - 54)

3.46

58.95

IL-6

34 (24 - 49)

95 (64 - 111)

3.73

94.74

IL-8

30 (20 - 38)

66 (36 - 79)

3.83

83.77

MCP-1

17 (14 - 20)

56 (35 - 70)

3.95

48.34

Myeloperoxidase

36 (31 - 41)

83 (47 - 103)

5.39

100.83

TIMP-1

16 (14 - 18)

18 (13 - 21)

5.89

47.23

VEGF

19 (14 - 27)

63 (28 - 79)

4.98

54.41

Median coefficient of variation for all proteins

32

59

6.05

91.05