Table 2 Mean serum protein concentrations averaged over the 3 patient visits:
Serum Protein | COPD non-smokers (N = 13) | COPD smokers (N = 8) | Control non-smokers (N = 12) | Control smokers (N = 9) | P value COPD vs controls |
|---|---|---|---|---|---|
Eotaxin2 (pg/ml) # | 554.2 (352.5) | 465.6 (327.4) | 364.3 (158.3) | 475.5 (766.1) | 0.025 |
IP-10 (pg/ml) # | 170.2 (95.2) | 164.8 (126.4) | 125.8 (26.4) | 100.7 (44.3) | 0.22 |
TNF-R1 (pg/ml) # | 1489.4 (303.0) | 1312.1 (257.3) | 1430.9 (268.9) | 1442.7 (268.0) | 0.67 |
TNF-RII (pg/ml) # | 194.0 (118.8) | 268.4 (143.8) | 241.9 (116.2) | 235.9 (33.9) | 0.10 |
TIMP-2 (pg/ml) # | 25028.7 (5273.1) | 27639.6 (4570.7) | 30286.8 (4946.8) | 26514.6 (6425.1) | 0.046 |
HGF (pg/ml) # | 21112.5 (12544.1) | 19937.9 (10785.1) | 24076.2 (14625.4) | 25125.4 (9975.2) | 0.56 |
KGF (pg/ml) # | 82.1 (34.5) | 56.9 (26.0) | 65.3 (20.8) | 66.1 (15.7) | 0.94 |
MMP-13 (pg/ml) # | 1768.8 (2561.6) | 718.9 (450.6) | 774.5 (421.6) | 733.6 (328.7) | 0.58 |
GROα (pg/ml) # | 123.3 (61.4) | 93.4 (33.6) | 114.8 (53.0) | 113.6 (65.9) | 0.21 |
CRP (ug/ml)* | 13.6 (11.4) | 7.8 (9.1) | 4.1 (3.2) | 4.4 (4.0) | 0.042 |
ENA-78 (ng/ml)* | 2.3 (2.69) | 1.8 (0.6) | 2.5 (1.7) | 2.9 (1.9) | 0.13 |
IL-13(pg/ml)* | 37.5 (7.0) | 46.8 (13.4) | 40.4 (10.3) | 37.9 (7.9) | 0.17 |
IL-18 (pg/ml)* | 302.1 (165.4) | 329.0 (106.7) | 281.9 (170.9) | 256.3 (109.1) | 0.17 |
IL-6 (pg/ml)* | 8.0 (7.1) | 6.4 (5.1) | 2.3 (0.7) | Below detection limits | 0.20 |
IL-8 (pg/ml)* | 15.1 (12.1) | 11.4 (3.7) | 11.1 (3.4) | 11.5 (3.9) | 0.30 |
MCP-1 (pg/ml)* | 279.1 (181.5) | 259.7 (101.1) | 182.3 (35.6) | 198.7 (42.4) | 0.16 |
Myeloperoxidase (ng/ml)* | 523.7 (546.2) | 597.9 (298.9) | 379.6 (308.8) | 430.3 (248.9) | 0.031 |
TIMP-1 (ng/ml)* | 162.7 (33.1) | 160.7 (21.2) | 162.3 (31.5) | 146.0 (33.2) | 0.61 |
VEGF (pg/ml)* | 753.1 (217.9) | 999.5 (826.2) | 586.2 (192.1) | 674.5 (149.4) | 0.035 |