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Table 2 Mean serum protein concentrations averaged over the 3 patient visits:

From: Multi analyte profiling and variability of inflammatory markers in blood and induced sputum in patients with stable COPD

Serum Protein COPD non-smokers
(N = 13)
COPD smokers
(N = 8)
Control non-smokers
(N = 12)
Control smokers
(N = 9)
P value
COPD vs controls
Eotaxin2 (pg/ml) # 554.2 (352.5) 465.6 (327.4) 364.3 (158.3) 475.5 (766.1) 0.025
IP-10 (pg/ml) # 170.2 (95.2) 164.8 (126.4) 125.8 (26.4) 100.7 (44.3) 0.22
TNF-R1 (pg/ml) # 1489.4 (303.0) 1312.1 (257.3) 1430.9 (268.9) 1442.7 (268.0) 0.67
TNF-RII (pg/ml) # 194.0 (118.8) 268.4 (143.8) 241.9 (116.2) 235.9 (33.9) 0.10
TIMP-2 (pg/ml) # 25028.7 (5273.1) 27639.6 (4570.7) 30286.8 (4946.8) 26514.6 (6425.1) 0.046
HGF (pg/ml) # 21112.5 (12544.1) 19937.9 (10785.1) 24076.2 (14625.4) 25125.4 (9975.2) 0.56
KGF (pg/ml) # 82.1 (34.5) 56.9 (26.0) 65.3 (20.8) 66.1 (15.7) 0.94
MMP-13 (pg/ml) # 1768.8 (2561.6) 718.9 (450.6) 774.5 (421.6) 733.6 (328.7) 0.58
GROα (pg/ml) # 123.3 (61.4) 93.4 (33.6) 114.8 (53.0) 113.6 (65.9) 0.21
CRP (ug/ml)* 13.6 (11.4) 7.8 (9.1) 4.1 (3.2) 4.4 (4.0) 0.042
ENA-78 (ng/ml)* 2.3 (2.69) 1.8 (0.6) 2.5 (1.7) 2.9 (1.9) 0.13
IL-13(pg/ml)* 37.5 (7.0) 46.8 (13.4) 40.4 (10.3) 37.9 (7.9) 0.17
IL-18 (pg/ml)* 302.1 (165.4) 329.0 (106.7) 281.9 (170.9) 256.3 (109.1) 0.17
IL-6 (pg/ml)* 8.0 (7.1) 6.4 (5.1) 2.3 (0.7) Below detection limits 0.20
IL-8 (pg/ml)* 15.1 (12.1) 11.4 (3.7) 11.1 (3.4) 11.5 (3.9) 0.30
MCP-1 (pg/ml)* 279.1 (181.5) 259.7 (101.1) 182.3 (35.6) 198.7 (42.4) 0.16
Myeloperoxidase (ng/ml)* 523.7 (546.2) 597.9 (298.9) 379.6 (308.8) 430.3 (248.9) 0.031
TIMP-1 (ng/ml)* 162.7 (33.1) 160.7 (21.2) 162.3 (31.5) 146.0 (33.2) 0.61
VEGF (pg/ml)* 753.1 (217.9) 999.5 (826.2) 586.2 (192.1) 674.5 (149.4) 0.035
  1. Values in brackets are the standard deviations of the mean.
  2. P values were assessed using linear mixed effects models adjusted for age and gender (see methods section for details).
  3. # = Measured using SearchLight multiplex sandwich ELISA
  4. * = Measured using Luminex bead- based suspension array assays
  5. IP-10 = interferon-inducible protein 10, TNF-R1 = tumour necrosis factor receptor I, TNF-RII = tumour necrosis factor receptor 2, TIMP-2 = tissue inhibitors of metalloproteinases 2, HGF = hepatocyte growth factor, KGF = keratinocyte growth factor, MMP-13 = matrix metalloproteinase 13, GROα = growth-related oncogene alpha, CRP = C-reactive protein, ENA-78 = epithelial neutrophil-activating peptide 78, IL = interleukin, MCP-1 = monocyte chemotactic protein 1, TIMP-1 = tissue inhibitors of metalloproteinases 1, VEGF = vascular endothelial growth factor.
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