via i.c.v attenuates the antigen-induced changes of pulmonary function in rats, and U75302 blocks the inhibitory effect of LTB
. On day 21 after ovalbumin sensitization, rats were challenged for 5 min with aerosolized 2% ovalbumin and the airway resistance (R
) (A) and dynamic lung compliance (C
) (B) were measured before and 5 min after the antigen challenge. Data are expressed as the mean ± S.D of vehicle-sham (n = 8), vehicle-OVA (n = 10), LTB4-OVA (n = 9), U75302-OVA (n = 9) and U75302-LTB4-OVA (n = 10). ##P < 0.01 vs the vehicle-sham group; **P < 0.01 vs the vehicle-OVA group; ††P < 0.01 vs the LTB4-OVA group.