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Figure 1 | Respiratory Research

Figure 1

From: Intracerebroventricular injection of leukotriene B4 attenuates antigen-induced asthmatic response via BLT1 receptor stimulating HPA-axis in sensitized rats

Figure 1

LTB 4 via i.c.v attenuates the antigen-induced changes of pulmonary function in rats, and U75302 blocks the inhibitory effect of LTB 4 . On day 21 after ovalbumin sensitization, rats were challenged for 5 min with aerosolized 2% ovalbumin and the airway resistance (R L ) (A) and dynamic lung compliance (C dyn ) (B) were measured before and 5 min after the antigen challenge. Data are expressed as the mean ± S.D of vehicle-sham (n = 8), vehicle-OVA (n = 10), LTB4-OVA (n = 9), U75302-OVA (n = 9) and U75302-LTB4-OVA (n = 10). ##P < 0.01 vs the vehicle-sham group; **P < 0.01 vs the vehicle-OVA group; ††P < 0.01 vs the LTB4-OVA group.

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