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Figure 3 | Respiratory Research

Figure 3

From: A prostacyclin analogue, iloprost, protects from bleomycin-induced pulmonary fibrosis in mice

Figure 3

Effect of iloprost on thickened areas of alveolar septum, histopathological scorings and hydroxyproline content in lung tissue. A. Using digital imaging, the thickened areas of alveolar septum in the mice treated with Bleo (no iloprost) was significantly increased compared to those with Bleo+iloprost at day 14. Results are expressed as mean ± SEM, n = 6-8 mice per group, ***p < 0.001. B, semi-quantitative assessment was performed on day 14 using Aschroft scoring method, a significantly higher score was observed in the mice treated with Bleo (no iloprost) than those treated with Bleo+iloprost. Results are expressed as mean ± SEM, n = 5-8 mice per group, *** p < 0.001. C, the hydroxyproline content in lung tissue was significantly higher in the mice treated with Bleo (no iloprost) than those treated with Bleo+iloprost. Results are expressed as mean ± SEM, n = 5-7 mice per group, * p < 0.05.

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