Expression, regulation and clinical significance of soluble and membrane CD14 receptors in pediatric inflammatory lung diseases

Table 2 The value of sCD14 in serum and BALF compared to CRP and WBC for diagnosing bacterial pneumonia in children.

	sCD14 serum	CRP	WBC	sCD14 BALF
Sensitivity¹ [%]	93.6	80.7	64.5	41.9
Specificity² [%]	100	100	96.8	96.8
Diagnostic accuracy³ [%]	97.9⁴	93.6	86.0	78.5
Area under the ROC curve [%]	99.8	93.1	87.9	69.0
Cut-off value	8444 ng/ml	30 mg/l	14.0 × 10⁹	55 ng/ml

¹ Sensitivity is defined as the probability that a patient with pneumonia shows elevated levels of the respective marker at the specific cut-off level.
² Specificity is defined as the probability that a patient without pneumonia shows levels of the respective marker below the specific cut-off level.
³ Diagnostic accuracy is defined as the number of correctly positive categorized plus the number of correctly negative categorized as percentage of all.
⁴ The same diagnostic accuracy (97.9%) was reached for sCD 14 in serum at a cut-off value of 5429 ng/ml resulting in a sensitivity of 100% and a specificity of 96.8%.

ISSN: 1465-993X