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Figure 6 | Respiratory Research

Figure 6

From: Nrf2 protects against pulmonary fibrosis by regulating the lung oxidant level and Th1/Th2 balance

Figure 6

Lung Th1/Th2 balance is shifted toward Th2 inNrf2-/-mice. (A) The expression of IL-4, IL-13, and IFN-γ in the lungs of WT mice (open bars) or Nrf2-/- mice (solid bars) 7 days after treatment with saline or bleomycin (bleo). GAPDH was used as an internal control. n = 6 in each group. (B-C) The left panels show the proportion of CXCR3-positive (B) or CCR3-positive (C) cells among CD4-positive cells or among CD8-positive cells obtained from WT mice (open bars) or Nrf2-/- mice (solid bars) 7 days after treatment with saline or bleomycin (bleo). n = 6 in each group. The right panels show the proportion of IFN-γ-producing (B) or IL-4-producing (C) cells among CD4-positive cells or among CD8-positive cells obtained from WT mice or Nrf2-/- mice (KO) 7 days after treatment with bleomycin. n = 6 in each group. (D) The expression of T-bet and GATA-3 in the lymphocytes obtained from the lungs of WT mice (open bars) or Nrf2-/- mice (solid bars) 7 days after treatment with saline or bleomycin (bleo). GAPDH was used as an internal control. n = 6 in each group. *Significantly different (p < 0.05) between WT mice and Nrf2-/- mice.

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