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Table 4 Pharmacokinetic Analysis for GSK256066.

From: The inhaled phosphodiesterase 4 inhibitor GSK256066 reduces allergen challenge responses in asthma

Parameter

unit

Day 1

Day 7

AUC (0-t)

pg.h./mL

36.8 (93)

64.8 (89)

Cmax

Pg/mL

18.3 (68)

17.3 (63)

Tmax

h

1.0 (0.17-3.00)

1.0 (0.17-11.0)

Tlast

h

3.0 (0.5-6.0)

4.0 (1.0-24)

  1. Values are geometric means (CV%) for AUC(0-t) and Cmax, and medians (range) for Tmax and Tlast. 0-t = From 0 hrs to time of last measurable concentration. N = 18 on Day 1, and n = 17 on Day 7.
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Respiratory Research

ISSN: 1465-993X

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