Table 2 Pathways significantly modulated by neutrophil depletion during LPS induced lung inflammation as found in MetaCore
Main cellular process | Modulated pathways | P value | Genes in pathway | |
|---|---|---|---|---|
expressed | total | |||
Cell cycle | Role of APC in cell cycle regulation | 1,012E-02 | 4 | 32 |
Spindle assembly and chromosome separation | 1,012E-02 | 4 | 32 | |
Immune response | IFN alpha/beta signalling pathway | 2,740E-05 | 6 | 24 |
Alternative complement pathway | 8,024E-03 | 4 | 30 | |
Oncostatin M signaling via MAPK | 1,683E-02 | 4 | 35 | |
NKG2D signalling | 4,297E-02 | 3 | 29 | |
IL-3 activation and signallng pathway | 4,685E-02 | 3 | 30 | |
Response to extracellular stimulus | Angiotensin signalling via STATs | 2,917E-02 | 3 | 25 |
Ligand dependent activation of the ESR-1/AP-1 pathway | 4,756E-02 | 2 | 13 | |
Other | Mucin expression in CF via IL-6, IL-17 signalling pathways | 3,926E-02 | 3 | 28 |