Table 2 Odds ratio (and 95% confidence intervals) for associations with asthma and current wheezing in the ISAAC population sample and the effect modification in the strata for atopy (N = 4,264)

AS N = 350/3835

CW N = 317/3776

AA N = 164/2830

AW N = 162/2800

NA N = 167/2830

NW N = 138/2800

rs3918241

TT/TA/AA N = 2856/964/88

AS 1.10 (0.53 - 2.29)

p = 0.806

CW 1.09 (0.50 - 2.38)

p = 0.832

AA 0.61 (0.15 - 2.52)

p = 0.488

AW 0.94 (0.29 - 3.05)

p = 0.920

NA 1.80 (0.76 - 4.25)

p = 0.173

NW 1.53 (0.54-4.28)

p = 0.418

rs2664538 (Q279R) *

AA/AG/GG N = 1655/1821/559

AS 1.27 (0.94 - 1.72)

p = 0.121

CW 1.33 (0.97 - 1.82)

p = 0.077

AA 0.92 (0.57 - 1.50)

p = 0.749

AW 0.81 (0.48 - 1.35)

p = 0.415

NA 1.66 (1.12 - 2.46)

p = 0.011*

NW 2.12 (1.40 - 3.20)

p < 0.001*

rs3918256

AA/AG/GG N = 1278/2008/806

AS 1.20 (0.92 - 1.57)

p = 0.175

CW 1.17 (0.88 - 1.55)

p = 0.285

AA 1.08 (0.72 - 1.61)

p = 0.706

AW 0.93 (0.61 - 1.42)

0.750

NA 1.42 (0.98 - 2.05)

p = 0.061

NW 1.60 (1.08 - 2.38)

p = 0.018

rs3787268 *

GG/GA/AA N = 2419/1310/187

AS 0.97 (0.56 - 1.66)

p = 0.906

CW 1.01 (0.58 - 1.77)

p = 0.968

AA 0.27 (0.07 - 1.11)

p = 0.052

AW 0.14 (0.02 - 0.99)

p = 0.021

NA 1.50 (0.79 - 2.83)

p = 0.213

NW 2.18 (1.17 - 4.06)

p = 0.012*