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Figure 6 | Respiratory Research

Figure 6

From: Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation

Figure 6

Effect of T0901317 on carrageenan-induced Fas ligand expression and on apoptosis as measured by TUNEL like staining. Positive staining for Fas ligand was observed in lung sections taken from carrageenan-treated mice pre-treated with vehicle (b, d) compared to sham-operated mice (a, d). In contrast, T0901317 (20 mg/kg) treatment reduced the degree of positive staining for FAS Ligand in the lung tissues (c, d). Positive TUNEL staining was observed in lung sections taken from carrageenan-treated mice pre-treated with vehicle (f, h). In contrast, tissue obtained from carrageenan treated mice pre-treated with T0901317 (20 mg/kg) demonstrated no apoptotic cells or fragments (g, h). Almost no apoptotic cells were observed in lungs of sham mice (e, h). The figure is representative of at least 3 experiments performed on different experimental days. ND: not detectable. Data are expressed as mean ± s.e.m. from n = 10 mice for each group. *P < 0.01 versus sham group. °P < 0.01 versus carrageenan.

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