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Figure 5 | Respiratory Research

Figure 5

From: Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation

Figure 5

Representative Western blots showing the effects of T0901317 on IκB-α degradation and nuclear NF-κ Bp65 expression after carrageenan (CAR) injection. Basal expression of IκB-α was detected in lung samples from sham-treated animals, whereas IκB-α levels were substantially reduced in lung tissues obtained from vehicle-treated animals at 4 h after carrageenan injection (a, a1). T0901317 (20 mg/kg) treatment prevented carrageenan-induced IκB-α degradation (a, a1). NF-κB p65 levels in the lung nuclear fractions were also significantly increased at 4 h after carrageenan injection compared to the sham-treated mice (b, b1). T0901317 treatment significantly reduced the levels of NF-κB p65 (b, b1). A representative blot of lysates obtained from 5 animals per group is shown and densitometry analysis of all animals is reported. The results in panel a1 and b1 are expressed as mean ± s.e.m. from n = 5/6 lung tissues for each group. ND: not detectable. *P < 0.01 versus sham group. °P < 0.01 versus carrageenan.

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