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Figure 1 | Respiratory Research

Figure 1

From: Effects of Liver × receptor agonist treatment on signal transduction pathways in acute lung inflammation

Figure 1

Effect of T0901317 on histological alterations of lung tissue 4 h after carrageenan-induced injury and on PMN infiltration in the lung. Lung sections taken from carrageenan-treated mice pre-treated with vehicle demonstrated edema, tissue injury (b, d) as well as infiltration of the tissue with neutrophils (see b1). Carrageenan-treated animals pre-treated with T0901317 (20 mg/kg i.p.) (c, d) demonstrated reduced lung injury and neutrophil infiltration. Original magnification: × 125. Section from a sham animals demonstrating the normal architecture of the lung tissue (a, d). The figure is representative of at least 3 experiments performed on different experimental days. MPO activity, index of PMN infiltration, was significantly elevated at 4 h after carrageenan (CAR) administration in vehicle-treated mice (e), if compared with sham mice (e). T0901317 significantly reduced in a dose dependent manner MPO activity in the lung (e). The figure is representative of at least 3 experiments performed on different experimental days. Data are expressed as mean ± s.e.m. from n = 10 mice for each group. ND: not detectable. *P < 0.01 versus sham group. °P < 0.01 versus carrageenan.

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