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Table 4 Association between year 15 serum adiponectin concentrations and change in lung function over 10 years (year 20-year 10); CARDIA "calendar years".

From: Serum adiponectin is positively associated with lung function in young adults, independent of obesity: The CARDIA study

Year 15 adiponectin quartiles (Q) 10 YEAR DECLINE IN LUNG FUNCTION PARAMETERS (95% CI)
  MODEL 1 (n = 2,056) MODEL 2 (n = 2,056)
  FVC (ml) ± SE
Q1 -383 ± 14 -374 ± 14
Q2 -385 ± 14 -383 ± 14
Q3 -389 ± 13 -392 ± 13
Q4 -383 ± 14 -390 ± 14
Q1 minusQ4 0 (-42, 42) 16 (-27, 59)
Slope of ln(adiponectin)* 7 (-27, 41) 22 (-14, 57)
  p for trend = 0.69 p for trend = 0.22
  FEV 1 (ml) ± SE
Q1 -348 ± 11 -343 ± 11
Q2 -352 ± 12 -351 ± 12
Q3 -367 ± 11 -369 ± 11
Q4 -360 ± 12 -364 ± 12
Q1 minus Q4 12 (-22, 46) 21 (-14, 56)
Slope of ln(adiponectin)* 19 (-9, 47) 28 (-1, 56)
  p for trend = 0.17 p for trend = 0.05
  FEV1/FVC (%) ± SE
Q1 -1.08 ± 0.17 -1.13 ± 0.18
Q2 -1.13 ± 0.18 -1.13 ± 0.18
Q3 -1.43 ± 0.17 -1.40 ± 0.17
Q4 -1.44 ± 0.18 -1.40 ± 0.18
Q1 minus Q4 0.36 (-0.17, 0.89) 0.27 (-0.27, 0.82)
Slope of ln(adiponectin)* 0.34 (-0.09, 0.77) 0.26 (-0.18, 0.71)
  p for trend = 0.11 p for trend = 0.24
  1. Note 1: Model 1 was adjusted for race, sex, center, age, age2, amount of self-reported physical activity, body mass index (BMI) and smoking status (never, former, current) all at year 15 and height, height2at year 0. Model 2 was adjusted for all covariates in model 1 and for ln(insulin resistance in HOMA units) and ln(CRP) at year 15 examination.
  2. Note 2: Quartile cutpoints for serum adiponectin concentrations are ≤6.99, 7.00-9.59, 9.60-14.39, and ≥ 14.40 mg/l. Mean ± standard deviation of ln(adiponectin) = 2.21 ± 0.62 mg/l
  3. * Unit of slope was selected to match the adiponectin difference across Q1 to Q4. It was ml/(median level of adiponectin in quartile 1 (4.8 mg/l) - median level of adiponectin in quartile 4 (18.0 mg/l)).