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Table 3 Association between year 15 serum adiponectin concentrations and year 20 lung function; CARDIA "calendar years".

From: Serum adiponectin is positively associated with lung function in young adults, independent of obesity: The CARDIA study

Year 15 adiponectin quartiles (Q) YEAR 20 LUNG FUNCTION PARAMETERS (95% CI)
  MODEL 1 (n = 2,056) MODEL 2 (n = 2,056)
  Year 20 FVC (ml) ± SE
Q1 3916 ± 24 3953 ± 24
Q2 3968 ± 25 3973 ± 25
Q3 4032 ± 23 4017 ± 23
Q4 3997 ± 26 3967 ± 25
Q1 minus Q4 -82 (-156, -7) -15 (-90, 61)
Slope of ln(adiponectin)* -75 (-135, -14) -13 (-75, 49)
  p for trend = 0.01 p for trend = 0.67
  Year 20 FEV 1 (ml) ± SE
Q1 3101 ± 20 3126 ± 20
Q2 3124 ± 21 3128 ± 20
Q3 3171 ± 19 3162 ± 19
Q4 3138 ± 21 3117 ± 21
Q1 minus Q4 -38 (-99, 24) 9 (-53, 72)
Slope of ln(adiponectin)* -42 (-92, 8) 1 (-50, 52)
  p for trend = 0.09 p for trend = 0.97
  Year 20 FEV1/FVC (%) ± SE
Q1 79.6 ± 0.3 79.5 ± 0.3
Q2 79.2 ± 0.3 79.2 ± 0.3
Q3 79.1 ± 0.2 79.1 ± 0.2
Q4 78.9 ± 0.3 79.0 ± 0.3
Q1 minus Q4 0.7 (-0.1, 1.5) 0.5 (-0.3, 1.4)
Slope of ln(adiponectin)* 0.45 (-0.19, 1.09) -0.30 (-0.37, 0.96)
  p for trend = 0.16 p for trend = 0.37
  1. Note 1: Model 1 was adjusted for race, sex, center, age, age2, amount of self-reported physical activity, body mass index (BMI) and smoking status (never, former, current) all at year 15 and height, height2at year 0. Model 2 was adjusted for all covariates in model 1 and for ln(insulin resistance in HOMA units) and ln(CRP) at year 15 examination.
  2. Note 2: Quartile cutpoints for serum adiponectin concentrations are ≤6.99, 7.00-9.59, 9.60-14.39, and ≥ 14.40 mg/l. Mean ± standard deviation of ln(adiponectin) = 2.21 ± 0.62 mg/l
  3. * Unit of slope was selected to match the adiponectin difference across Q1 to Q4. It was ml/(median level of adiponectin in quartile 1 (4.8 mg/l) - median level of adiponectin in quartile 4 (18.0 mg/l)).