Serum adiponectin is positively associated with lung function in young adults, independent of obesity: The CARDIA study

Table 3 Association between year 15 serum adiponectin concentrations and year 20 lung function; CARDIA "calendar years".

*Year 15 adiponectin quartiles (Q)*	YEAR 20 LUNG FUNCTION PARAMETERS (95% CI)
	MODEL 1 (n = 2,056)	MODEL 2 (n = 2,056)
	Year 20 FVC (ml) ± SE
Q1	3916 ± 24	3953 ± 24
Q2	3968 ± 25	3973 ± 25
Q3	4032 ± 23	4017 ± 23
Q4	3997 ± 26	3967 ± 25
Q1 minus Q4	-82 (-156, -7)	-15 (-90, 61)
Slope of ln(adiponectin)*	-75 (-135, -14)	-13 (-75, 49)
	p for trend = 0.01	p for trend = 0.67
	Year 20 FEV ₁ (ml) ± SE
Q1	3101 ± 20	3126 ± 20
Q2	3124 ± 21	3128 ± 20
Q3	3171 ± 19	3162 ± 19
Q4	3138 ± 21	3117 ± 21
Q1 minus Q4	-38 (-99, 24)	9 (-53, 72)
Slope of ln(adiponectin)*	-42 (-92, 8)	1 (-50, 52)
	p for trend = 0.09	p for trend = 0.97
	Year 20 FEV1/FVC (%) ± SE
Q1	79.6 ± 0.3	79.5 ± 0.3
Q2	79.2 ± 0.3	79.2 ± 0.3
Q3	79.1 ± 0.2	79.1 ± 0.2
Q4	78.9 ± 0.3	79.0 ± 0.3
Q1 minus Q4	0.7 (-0.1, 1.5)	0.5 (-0.3, 1.4)
Slope of ln(adiponectin)*	0.45 (-0.19, 1.09)	-0.30 (-0.37, 0.96)
	p for trend = 0.16	p for trend = 0.37

Note 1: Model 1 was adjusted for race, sex, center, age, age², amount of self-reported physical activity, body mass index (BMI) and smoking status (never, former, current) all at year 15 and height, height²at year 0. Model 2 was adjusted for all covariates in model 1 and for ln(insulin resistance in HOMA units) and ln(CRP) at year 15 examination.
Note 2: Quartile cutpoints for serum adiponectin concentrations are ≤6.99, 7.00-9.59, 9.60-14.39, and ≥ 14.40 mg/l. Mean ± standard deviation of ln(adiponectin) = 2.21 ± 0.62 mg/l
* Unit of slope was selected to match the adiponectin difference across Q1 to Q4. It was ml/(median level of adiponectin in quartile 1 (4.8 mg/l) - median level of adiponectin in quartile 4 (18.0 mg/l)).

ISSN: 1465-993X