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Table 2 Association between year 15 serum adiponectin concentrations and year 10 lung function; CARDIA "calendar years".

From: Serum adiponectin is positively associated with lung function in young adults, independent of obesity: The CARDIA study

Year 15 adiponectin quartiles (Q) YEAR 10 LUNG FUNCTION PARAMETERS (95% CI)
  MODEL 1 (n = 2,056) MODEL 2 (n = 2,056)
  Year 10 FVC (ml) ± SE
Q1 4298 ± 23 4327 ± 24
Q2 4353 ± 24 4357 ± 24
Q3 4420 ± 22 4409 ± 22
Q4 4380 ± 25 4357 ± 25
Q1 minus Q4 -81 (-153, -9) -30 (-103, 43)
Slope of ln(adiponectin)* -82 (-140, -23) -35 (-94, 25)
  p for trend = 0.005 p for trend = 0.25
  Year 10 FEV 1 (ml) ± SE
Q1 3448 ± 19 3469 ± 20
Q2 3476 ± 20 3479 ± 20
Q3 3539 ± 18 3531 ± 18
Q4 3498 ± 20 3481 ± 20
Q1 minus Q4 -50 (-109, 9) -12 (-72, 48)
Slope of ln(adiponectin)* -61 (-109, -13) -27 (-76, 23)
  p for trend = 0.01 p for trend = 0.28
  Year 10 FEV 1 /FVC (%) ± SE
Q1 80.7 ± 0.2 80.6 ± 0.3
Q2 80.3 ± 0.3 80.3 ± 0.3
Q3 80.5 ± 0.2 80.5 ± 0.2
Q4 80.3 ± 0.3 80.4 ± 0.3
Q1 minus Q4 0.4 (-0.4, 1.1) 0.3 (-0.5, 1.1)
Slope of ln(adiponectin)* 0.11 (-0.51, 0.73) 0.03 (-0.61, 0.68)
  p for trend = 0.73 p for trend = 0.92
  1. Note 1: Model 1 was adjusted for race, sex, center, age, age2, amount of self-reported physical activity, body mass index (BMI) and smoking status (never, former, current) all at year 15 and height, height2at year 0. Model 2 was adjusted for all covariates in model 1 and for ln(insulin resistance in HOMA units) and ln(CRP) at year 15 examination.
  2. Note 2: Quartile cutpoints for serum adiponectin concentrations are ≤6.99, 7.00-9.59, 9.60-14.39, and ≥ 14.40 mg/l. Mean ± standard deviation of ln(adiponectin) = 2.21 ± 0.62 mg/l
  3. * Unit of slope was selected to match the adiponectin difference across Q1 to Q4. It was ml/(median level of adiponectin in quartile 1 (4.8 mg/l) - median level of adiponectin in quartile 4 (18.0 mg/l)).