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Table 2 Studies connecting Vitamin C, E, A, alpha and beta-carotene with spirometric values improvement.

From: A systematic review of the role of vitamin insufficiencies and supplementation in COPD

Vitamin

FFQ studies

Plasma levels studies

Improvement in spirometric values

No association

with spirometric values

Vit C

31,58,59,60,61, 62,63,65,66

32,52, 63,69,70

Serum:FEV1 improvement in ml from 17-94 ml and FVC improvement from 16.4-94 ml for an SD variation

FFQ: FEV1 improvement in ml from 37-53 ml and FVC improvement from 23.3-79 ml for an SD variation

52

Vit E

31,58,59,61, 62,64,65

32,69,70

Serum: An SD increase in plasma levels of vitamin E had a median range of FEV1 increase in ml from 12-59.3 ml

FFQ: An SD increase had a median range of FEV1 increase in ml from 20.1-93 ml and for FVC from 23.1 -54 ml, respectivelly

31,58,61

Vit A

61,68

32,70

32,70

Serum:Improvement in FEV1 ranges from 22-31.2 ml

61,68

b-carotene

31,57, 63,65,66,69

32,69, 70, 76

Serum: Improvement in FEV1 ranges from 11-107 ml, FVC 147 ml

FFQ: Improvement in FEV1 = 60 ml, FVC= 75 ml

57

a-carotene

 

70,71

70,71

Serum:

Improvement in FEV1 for one SD increase 23.7 ml70.

Subjects in the fifth quintile of serum beta-carotene had a 195 ml (95% confidence interval [95% CI]: 40 to 351 ml) higher and those in the fifth quintile of alpha-carotene had a 257 ml (95% CI: 99 to 414 ml) higher FEV(1) compared with subjects in the first quintile of these carotenoids71.

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