From: A systematic review of the role of vitamin insufficiencies and supplementation in COPD
Vitamin | FFQ studies | Plasma levels studies | Improvement in spirometric values | No association with spirometric values |
---|---|---|---|---|
Vit C | 31,58,59,60,61, 62,63,65,66 | 32,52, 63,69,70 | Serum:FEV1 improvement in ml from 17-94 ml and FVC improvement from 16.4-94 ml for an SD variation FFQ: FEV1 improvement in ml from 37-53 ml and FVC improvement from 23.3-79 ml for an SD variation | 52 |
Vit E | 31,58,59,61, 62,64,65 | 32,69,70 | Serum: An SD increase in plasma levels of vitamin E had a median range of FEV1 increase in ml from 12-59.3 ml FFQ: An SD increase had a median range of FEV1 increase in ml from 20.1-93 ml and for FVC from 23.1 -54 ml, respectivelly | 31,58,61 |
Vit A | 61,68 | 32,70 | 32,70 Serum:Improvement in FEV1 ranges from 22-31.2 ml | 61,68 |
b-carotene | 31,57, 63,65,66,69 | 32,69, 70, 76 | Serum: Improvement in FEV1 ranges from 11-107 ml, FVC 147 ml FFQ: Improvement in FEV1 = 60 ml, FVC= 75 ml | 57 |
a-carotene | Â | 70,71 | 70,71 Serum: Improvement in FEV1 for one SD increase 23.7 ml70. Subjects in the fifth quintile of serum beta-carotene had a 195 ml (95% confidence interval [95% CI]: 40 to 351 ml) higher and those in the fifth quintile of alpha-carotene had a 257 ml (95% CI: 99 to 414 ml) higher FEV(1) compared with subjects in the first quintile of these carotenoids71. | Â |