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Figure 3 | Respiratory Research

Figure 3

From: Effects of a dual CCR3 and H1-antagonist on symptoms and eosinophilic inflammation in allergic rhinitis

Figure 3

Tryptase (A), ECP (B), and α 2 -macroglobulin (C) in lavages obtained late into the allergen challenge series prior to and after bradykinin challenge (median values with interquartile ranges). AZD3778 reduced the levels of ECP in lavages obtained prior to as well as after bradykinin challenge (c.f. placebo). Whereas this change reached borderline statistical significance prior to bradykinin challenge (p = 0.08), it was statistically significant after the challenge. In contrast to AZD3778, loratadine failed to reduce the levels of ECP (c.f. placebo). Furthermore, ECP recorded at AZD3778 treatment were significantly lower compared to at treatment with loratadine. The treatments all failed to reduce the lavage fluid levels of tryptase and α2-macroglobulin (*Denotes p < 0.05 and ***denotes p < 0.001.)

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