Figure 1

A. Tryptase (A), ECP (B), and α ₂ -macroglobulin (C) in lavages obtained at baseline (before allergen challenge) and in corresponding lavages late into the allergen challenge series (prior to bradykinin challenge) in the placebo run (median values with interquartile ranges). The allergen challenge series produced an inflammatory response characterized by increased mast cell and eosinophil activity as well as by plasma exudation. (*Denotes p < 0.05, ***denotes p < 0.001, and ****denotes p < 0.0001.)