Figure 3
10 μM Histamine (HA) increased NCX1 mediated outwardly rectifying currents and are inhibited by 10 μM KB-R7943. (A) Time course of current density (at +80 mV). Control (triangles, n = 12), HA (diamonds, n = 10) and HA+KB-R7943 (squares, n = 13). (B)Bar chart illustrating peak current density of these HA induced outwardly rectifying currents with (n = 13) or without KB-R7943 (n = 10) mean data ± SEM, **p < 0.01. C) Representative traces of I-V relationships of currents induced by re-addition of extracellular Ca2+ and HA ± KB-R7943. Note that in panel 3A baseline currents (0 Ca2+) have been subtracted from all traces.