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Table 1 Patient characteristics of the immunohistochemical samples

From: Variability in the precursor proteins of collagen I and III in different stages of COPD

  Non-smokers n = 16 Smokers n = 20 COPD stage I-II n = 20 COPD stage IV n = 8 p-value
Age, years 65 (13)** 63 (8) 65 (7) 54 (8) 0.039
Sex M:F 8:8 15:5 16:4 5:3 0.096
Pack-years 0* 46 (20) 39 (14) 34 (18) < 0.001
FEV1 l/s 2.96 (1.19)§ 3.02 (0.71) 2.2 (0.54) 0.66 (0.24) < 0.001
FEV1 %predicted 98 (15) 91 (9)# 68 (13) 21 (12) < 0.001
FEV1 postbd 2.98 (1.1) 3.26 (0.81) 2.23 (0.38) NA  
FVC 3.44 (1.3) 3.59 (0.91) 3.51 (1.1) 1.78 (1.0) < 0.001
FVC postbd 3.46 (1.21) 3.79 (1.1) 3.66 (1.16) NA  
FEV1/FVC % 86 (9)* 84 (11)# 60 (8) 37 (13) < 0.001
DCO %predicted 91 (15)** 77 (15)§§ 75 (10) 29 (8) < 0.001
DCO/VA %predicted 89 (11)** 82 (12)§§ 77 (21) 46 (11) < 0.001
  1. Mean (SD)
  2. *The mean difference between non-smokers and smokers is significant at the 0.05 level, Dunnett t-test.
  3. § The mean difference between non-smokers and COPD-patients is significant at the 0.05 level, Dunnett t-test.
  4. # The mean difference between smokers and COPD-patients is significant at the 0.05 level, Dunnett t-test.
  5. ** The mean difference between non-smokers and patients with severe COPD (GOLD stage IV) is significant at the 0.05 level, Dunnett t-test
  6. §§ The mean difference between smokers and patients with severe COPD (GOLD stage IV) is significant at the 0.05 level, Dunnett t-test