Table 4 MiRNAs involved in physiological processes in the lung.

miR-17-92 cluster

important in lung development and homeostasis (A)

[69, 76, 77]

miR-155

important for normal lung airway remodelling (A)

[70]

alteration of T-cell differentiation (A)

[71]

miR-26a

highly expressed within bronchial and alveolar epithelial cells, important for lung development (H)

[75]

let-7

highly expressed in normal lung tissue, functions as a tumor suppressor in lung cells (H)

[78]

miR-29

functions as tumor suppressor in lung cells (H)

[79]

miR-15, miR-16

function as tumor suppressor genes (H)

[80, 81]

miR-223

control of granulocyte development and function (A)

[82]

miR-146a/b

central to the negative feedback regulation of IL-1β-induced inflammation (H)

[83, 84]

miR-200a, miR-223

contribution to the extreme virulence of the r1918 influenza virus (A)

[85]

miR-17 family, miR-574-5p, miR-214

upregulated at the onset of SARS infection (A, H)

[86]