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Figure 5 | Respiratory Research

Figure 5

From: Chronic OVA allergen challenged Siglec-F deficient mice have increased mucus, remodeling, and epithelial Siglec-F ligands which are up-regulated by IL-4 and IL-13

Figure 5

Levels of lung cytokines and chemokines in Siglec-F deficient vs WT mice. Different groups of Siglec-F deficient or WT mice were subjected to chronic OVA challenge. Non-OVA challenged mice served as a control. Levels of IL-5 (Fig 5A), IL-13 (Fig 5B), eotaxin-1 (Fig 5C), and RANTES (Fig 5D) were measured in lung by ELISA. Chronic OVA challenge in WT mice induced a significant increase in IL-5 (p < 0.03*)(Fig 5A), IL-13 (p < 0.04*)(Fig 5B), and eotaxin-1 (p < 0.01*)(Fig 5C), but not RANTES (p = ns)(Fig 5D). Levels of IL-5 (Fig 5A) and IL-13 (Fig 5B) were no different in OVA challenged Siglec-F deficient mice compared to WT mice challenged with OVA, while levels of eotaxin-1 (p < 0.04#) (Fig 5C) and RANTES (p < 0.02#)(Fig 5D) were increased in Siglec-F deficient mice compared to WT mice challenged with OVA (n = 16 mice/group).

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