Table 7 The role of leptin in lung cancer
From: The role of leptin in the respiratory system: an overview
Reference (year) | Main messages | Main limitations |
|---|---|---|
Ribeiro et al138 (2006) | Polymorphism in the promoter of leptin gene associated with increased risk for NSCLC | Controls younger than patient group/Smoking status of controls unknown |
Aleman et al142 (2002) | Lower leptin in NSCLC vs controls | No adjustment for FM/Only advanced stage disease |
Karapanagiotou et al146 (2008) | No association of leptin to histological type, differentiation grade, disease stage, survival or time to disease progression | Controls and patients not age and sex matched/ Only advanced stage disease |
Carpagnano et al147 (2007) | Higher leptin in NSCLC vs controls | No adjustment for FM/Limited number o f patients/Non-advanced disease stage |