Table 1 Effects of leptin signaling in lung cells

Vernooy et al⁸ (2009)

Increased leptin and Ob-Rb expression in bronchial epithelial cells following smoke exposure

Leptin induces phosphorylation of STAT-3 in NCI-H292 and A549 cell lines

Cells obtained from lung cancer patients who underwent lung surgery (disease free areas)

A549 is a human alveolar epithelial cell line-NCI-H292 is a human bronchial epithelial cell line

Bruno et al⁹ (2009)

Leptin increases cell proliferation and decreases TGF-β release in 16HBE cell line

TGF-β decreases and fluticasone propionate increases leptin receptor expression in 16HBE cell line

16HBE is a human bronchial epithelial cell line

Nair et al⁴⁷ (2008)

Leptin inhibits PDGF-airway smooth muscle migration and proliferation and IL-13-induced eotaxin production

Cells obtained from lung cancer patients who underwent lung surgery (disease free areas)

Tsuchiya et al⁴⁹ (1999)

Leptin induces cell proliferation in SQ-5 cells by increasing the MAP kinase activity

SQ-5 is a clonal cell line derived from human lung squamous cell cancer