Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep

Table 2 Saturated phosphatidylcholine levels and indices of injury

	Sat PC < 5 (n = 18)	Sat PC > 5 (n = 10)	p value
Description of Animals
Birth weight (kg)	3.5 ± 0.1	3.5 ± 0.1	= 1
Gender (male:female)	10:8	6:4	= 1
Gestational Age (days)	133.1	133.1	= 1
BAL Sat PC (μmol/kg)	2.5 ± 0.3	10.6 ± 1.4*	< 0.001
V _T and Compliance
V_T/kg at 5 min (mL/kg)	10.2 ± 0.6	10.8 ± 0.7	= 1
V_T/kg at 10 min (mL/kg)	14.4 ± 0.4	14.3 ± 0.5	= 1
V_T/kg at 15 min (mL/kg)	15.6 ± 0.6	16.5 ± 0.5	= 1
Compliance 5 min (mL/cmH₂0/kg)	0.28 ± 0.02	0.31 ± 0.03	= 0.50
Compliance 10 min (mL/cmH₂0/kg)	0.34 ± 0.01	0.39 ± 0.02	= 0.11
Compliance 15 min (mL/cmH₂0/kg)	0.36 ± 0.02	0.42 ± 0.02	= 0.06
BAL Fluid
Protein (mg/kg)	94.4 ± 9.0	52.4 ± 7.8	< 0.002
Neutrophils (x10⁶/kg)	74.2 ± 1.8	16.2 ± 9.6	< 0.01
Monocytes (x10⁶/kg)	12.3 ± 2.9	8.9 ± 1.3	= 0.49
MCP-1 protein (ng/ml)	42.1 ± 5.6	7.2 ± 3.2	< 0.0001
Lung Tissue (mRNA fold increase)
IL-1β	19.2 ± 2.3	6.2 ± 1.3	< 0.0001
IL-6	49.9 ± 8.0	7.2 ± 1.8	< 0.001
IL-8	24.8 ± 4.8	6.7 ± 0.8	< 0.0001
Injury Scores
(Out of 8 total points)	4.8 ± 0.2	3.0 ± 0.5	= 0.02

V_T = tidal volume, BAL = bronchoalveolar lavage fluid, Sat PC = saturated phosphatidylchloline.
BW = birth weight, Compliance = (VT/kg)/(PIP-PEEP) * p < 0.05 vs Sat PC < 5.

ISSN: 1465-993X