Inhibitors of inflammation and endogenous surfactant pool size as modulators of lung injury with initiation of ventilation in preterm sheep

Table 1 Animals grouped by inhibitor treatments

	N	BW	V_T 15 min	V_T 2 h	BALF Protein	BALF Inflammatory cells	BALF MCP-1	IL-1β mRNA	IL-6 mRNA	IL-8 mRNA
			mL/kg		mg/kg	x10 ⁶ /kg	ng/mL	fold increase
Controls	7	3.2 ± 0.1	None		23 ± 6	1.2 ± 1.0	0.6 ± 0.6	1 ± 0.2	1 ± 0.2	1 ± 0.1
No Inhibitor	7	3.5 ± 0.2	15.7 ± 0.5	8.6 ± 0.8	82 ± 11*	81 ± 23*	28 ± 7*	16 ± 4*	43 ± 14*	28 ± 12*
NF-κB Inhbitor	7	3.6 ± 0.1	16.2 ± 1.1	9.3 ± 0.4	92 ± 18*	101 ± 34*	44 ± 10*	21 ± 4*	53 ± 11*	24 ± 5*
IL-8 Inhibitor	7	3.3 ± 0.1	15.5 ± 1.4	10.9 ± 0.9	72 ± 11*	63 ± 29*	32 ± 13*	14 ± 5*	20 ± 7*	12 ± 3*
IL-1 Inhibitor	7	3.6 ± 0.2	16.4 ± 0.7	9.6 ± 0.7	72 ± 18*	33 ± 11*	13 ± 7*	7 ± 2*	23 ± 15*	9 ± 3*

ISSN: 1465-993X