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Table 2 Expression of GABAergic System Genes in Large Airway and Small Airway Epithelium of Healthy Smokers Compared to Healthy Nonsmokers1

From: Smoking-mediated up-regulation of GAD67 expression in the human airway epithelium

   

Large airway(smoker/nonsmoker)2

Small airway (smoker/nonsmoker)2

Probe set ID

Gene symbol

Gene title

Fold-change

p value 3

P call (%) 4

Fold-change

p value 3

P call (%) 4

Synthesis

        

   206780_at

GAD65

glutamate decarboxylase 2

1.08

0.86

0.0

1.05

0.89

0.0

   205278_at

GAD67

glutamate decarboxylase 1

4.09

2.07 × 10-5

80.8

6.27

2.33 × 10-11

59.0

Receptor

        

   244118_at

GABRA1

gamma-aminobutyric acid (GABA) A receptor, alpha 1

-1.27

0.60

1.9

1.12

0.84

1.9

   207014_at

GABRA2

gamma-aminobutyric acid (GABA) A receptor, alpha 2

-1.26

0.60

0.00

1.12

0.83

1.0

   207210_at

GABRA3

gamma-aminobutyric acid (GABA) A receptor, alpha 3

1.80

0.16

0.00

1.17

0.69

1.0

   208463_at

GABRA4

gamma-aminobutyric acid (GABA) A receptor, alpha 4

1.21

0.63

7.7

1.05

0.89

6.7

   215531_s_at

GABRA5

gamma-aminobutyric acid (GABA) A receptor, alpha 5

-1.46

0.46

1.9

1.01

0.95

1.0

   207182_at

GABRA6

gamma-aminobutyric acid (GABA) A receptor, alpha 6

1.07

0.91

0.0

1.49

0.20

0.0

   207010_at

GABRB1

gamma-aminobutyric acid (GABA) A receptor, beta 1

1.38

0.57

9.6

-1.14

0.81

6.7

   242344_at

GABRB2

gamma-aminobutyric acid (GABA) A receptor, beta 2

1.34

0.33

61.5

1.15

0.70

41.9

   229724_at

GABRB3

gamma-aminobutyric acid (GABA) A receptor, beta 3

-1.01

0.98

96.2

1.10

0.81

97.1

   241805_at

GABRG1

gamma-aminobutyric acid (GABA) A receptor, gamma 1

1.09

0.86

15.4

-1.11

0.82

33.3

   1568612_at

GABRG2

gamma-aminobutyric acid (GABA) A receptor, gamma 2

1.02

0.96

0.0

1.34

0.49

0.0

   216895_at

GABRG3

gamma-aminobutyric acid (GABA) A receptor, gamma 3

-1.10

0.86

9.6

-1.74

0.14

14.3

   204537_s_at

GABRE

gamma-aminobutyric acid (GABA) A receptor, epsilon

1.13

0.56

98.1

-1.29

0.12

72.4

   220886_at

GABRQ

gamma-aminobutyric acid (GABA) receptor, theta

1.34

0.56

1.9

-1.03

0.91

1.0

   230255_at

GABRD

gamma-aminobutyric acid (GABA) A receptor, delta

1.15

0.51

0.0

-1.02

0.91

0.0

   5044_at

GABRP

gamma-aminobutyric acid (GABA) A receptor, pi

1.08

0.70

100.0

-1.07

0.81

100.0

   206525_ at

GABRR1

gamma-aminobutyric acid (GABA) receptor, rho 1

1.81

0.29

23.1

-1.27

0.53

15.2

   208217_at

GABRR2

gamma-aminobutyric acid (GABA) receptor, rho 2

-1.12

0.73

11.5

1.24

0.20

21.9

   234410_at

GABRR3

gamma-aminobutyric acid (GABA) receptor, rho 3

1.09

0.86

0.0

1.41

0.26

1.0

   205890_s_at

GABBR1

gamma-aminobutyric acid (GABA) B receptor, 1

-1.45

0.31

94.2

-1.75

1.79 × 10-4

98.1

   209990_s_at

GABBR2

gamma-aminobutyric acid (GABA) B receptor, 2

-1.09

0.86

15.4

-1.33

0.42

7.6

Transport

        

   205152_at

GAT-1

solute carrier family 6 (neurotransmitter transporter, GABA), member 1

-1.37

0.46

26.9

-1.70

0.14

44.7

   237058_x_at

GAT-2

solute carrier family 6 (neurotransmitter transporter, GABA), member 13

-1.35

0.30

100.0

-1.13

0.60

99.1

   207048_at

GAT-3

solute carrier family 6 (neurotransmitter transporter, GABA), member 11

-1.09

0.86

1.9

1.14

0.69

1.0

   206058_at

BGT-1

solute carrier family 6 (neurotransmitter transporter, betaine/GABA), member 12

-1.18

0.70

17.3

-1.04

0.90

8.6

   240532_at

VGAT

solute carrier family 32 (GABA vesicular transporter), member 1

1.03

0.95

0.0

-1.15

0.69

0.0

Metabolism

        

   209460_at

GABA-T

4-aminobutyrate aminotransferase

-1.45

7.25 × 10-2

100.0

-1.45

5.41 × 10-3

100.0

   203608_at

ALDH5A1

aldehyde dehydrogenase 5 family, member A1

-1.18

0.31

100.0

-1.15

0.12

100.0

  1. 1Data was obtained using the Affymetrix HG-U133 Plus 2.0 microarray chip.
  2. 2Fold-change represents the ratio of average expression value in healthy smokers to average expression value in healthy nonsmokers. Positive fold-changes represent genes up-regulated by smoking; negative fold-changes represent genes down-regulated by smoking.
  3. 3p value obtained using Benjamini-Hochberg correction to limit the false positive rate.
  4. 4P call represents the % of healthy nonsmoker and healthy smoker samples in which the Affymetrix detection call for that probe set was "P" or "Present," i.e., the gene was expressed in that sample.