Figure 3

Microarray assessment of smoking-induced change in GABAergic system gene expression in large and small airway epithelium. A. Volcano plot of GABAergic system gene-related probe sets in large airway epithelium. B. Volcano plot of GABAergic system gene-related probe sets in small airway epithelium. For both panels, the x-axis corresponds to the fold-change and the y-axis corresponds to p value. Black dots represent significant differentially expressed probe sets; open dots represent probe sets with no significant difference between healthy smokers and healthy nonsmokers. The changes in gene expression were considered significant based on the criteria of fold-change >2, p < 0.01, with Benjamini-Hochberg correction