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Table 5 Summary of responses of key experimental groups

From: Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice

  Allergic inflammation Th2 response Airway remodelling AHR
Early-life infection alone - - + +++
Sensitisation and challenge alone + ± +++ +
Infection followed by sensitisation and challenge +++ +++ +++ +++
Infection followed by sensitisation and challenge in IL-4Rα-/- mice - - ++ -