Table 5 Summary of responses of key experimental groups
From: Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice
| Â | Allergic inflammation | Th2 response | Airway remodelling | AHR |
|---|---|---|---|---|
Early-life infection alone | - | - | + | +++ |
Sensitisation and challenge alone | + | ± | +++ | + |
Infection followed by sensitisation and challenge | +++ | +++ | +++ | +++ |
Infection followed by sensitisation and challenge in IL-4Rα-/- mice | - | - | ++ | - |