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Table 1 Inflammatory and epithelial changes in the airways and lungs

From: Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice

 

Experimental groups

 

Naive

Virus control

Sham/sham

Sham/OVA

Virus/nil

Virus/OVA

OVA/sham

Virus+OVA/nil

Virus/OVA IL-4Rα -/-

Intrapulmonary CD3+ T cells/mm2

2.8 (0.8)

7.2 (0.9)

3.3 (0.6)#

8.0 (1.3)

10.4 (3.2) *

10.2 (2.2) *

4.4 (0.9)

6.6 (0.8)

4.7 (1.2)

Intrapulmonary eosinophils/mm2

2.7 (0.6)

3.7 (0.9)#

1.5 (0.4)###

3.7 (1.1)#

3.0 (0.8)#

6.5 (0.6) ***

1.1 (0.5)###

5.7 (0.9)

0.9 (0.3)###

Lymphoid aggregates per section§

0.0 (0.75)

2.0 (3.25) *

0.0 (0.25)

0.0 (1.25)

1.0 (4.0)

1.0 (2.0)

0.5 (1.0)

1.0 (1.25)

2.5 (4.75) **

Lamina propria cells/100 μm basement membrane

19.2 (1.0)

22.3 (1.1)

19.6 (1.7)#

24.0 (1.2) *

24.8 (1.5) *

25.1 (1.2) *

20.0 (1.5)

22.0 (1.6)

21.7 (1.0)

Thickness of subepithelial collagen zone (μm)

3.2 (0.2)

4.0 (0.2)

2.7 (0.2)###

4.7 (0.2) ***

4.3 (0.2) **

4.8 (0.1) ***

4.2 (0.2) *

4.2 (0.2) *

4.4 (0.4) **

Thickness of epithelial cell layer (μm)

12.5 (0.5)

12.6 (0.8)#

12.1 (0.7)##

16.9 (0.5) ***

15.1 (0.7)

16.1 (1.3) *

14.6 (0.7)

13.7 (0.9)

16.2 (0.6) *

Grade of mucous cell metaplasia§

1.0 (1.0)

3.0 (3.0)*

0.0 (1.0)##

2.0 (2.0)

3.0 (2.0) **

3.0 (1.0) **

2.0 (2.0)

1.0 (2.0)

0.0 (0.0)###

  1. Data are presented as mean (S.E.M), except § which are median (interquartile range). Significant differences compared to naïve animals shown as * = P < 0.05, ** = P < 0.01, *** = P < 0.001; compared to virus-infected, OVA-challenged animals (Virus/OVA) shown as # = P < 0.05, ## = P < 0.01, ### = P < 0.001.