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Table 1 Inflammatory and epithelial changes in the airways and lungs

From: Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice

  Experimental groups
  Naive Virus control Sham/sham Sham/OVA Virus/nil Virus/OVA OVA/sham Virus+OVA/nil Virus/OVA IL-4Rα -/-
Intrapulmonary CD3+ T cells/mm2 2.8 (0.8) 7.2 (0.9) 3.3 (0.6)# 8.0 (1.3) 10.4 (3.2) * 10.2 (2.2) * 4.4 (0.9) 6.6 (0.8) 4.7 (1.2)
Intrapulmonary eosinophils/mm2 2.7 (0.6) 3.7 (0.9)# 1.5 (0.4)### 3.7 (1.1)# 3.0 (0.8)# 6.5 (0.6) *** 1.1 (0.5)### 5.7 (0.9) 0.9 (0.3)###
Lymphoid aggregates per section§ 0.0 (0.75) 2.0 (3.25) * 0.0 (0.25) 0.0 (1.25) 1.0 (4.0) 1.0 (2.0) 0.5 (1.0) 1.0 (1.25) 2.5 (4.75) **
Lamina propria cells/100 μm basement membrane 19.2 (1.0) 22.3 (1.1) 19.6 (1.7)# 24.0 (1.2) * 24.8 (1.5) * 25.1 (1.2) * 20.0 (1.5) 22.0 (1.6) 21.7 (1.0)
Thickness of subepithelial collagen zone (μm) 3.2 (0.2) 4.0 (0.2) 2.7 (0.2)### 4.7 (0.2) *** 4.3 (0.2) ** 4.8 (0.1) *** 4.2 (0.2) * 4.2 (0.2) * 4.4 (0.4) **
Thickness of epithelial cell layer (μm) 12.5 (0.5) 12.6 (0.8)# 12.1 (0.7)## 16.9 (0.5) *** 15.1 (0.7) 16.1 (1.3) * 14.6 (0.7) 13.7 (0.9) 16.2 (0.6) *
Grade of mucous cell metaplasia§ 1.0 (1.0) 3.0 (3.0)* 0.0 (1.0)## 2.0 (2.0) 3.0 (2.0) ** 3.0 (1.0) ** 2.0 (2.0) 1.0 (2.0) 0.0 (0.0)###
  1. Data are presented as mean (S.E.M), except § which are median (interquartile range). Significant differences compared to naïve animals shown as * = P < 0.05, ** = P < 0.01, *** = P < 0.001; compared to virus-infected, OVA-challenged animals (Virus/OVA) shown as # = P < 0.05, ## = P < 0.01, ### = P < 0.001.