From: Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice
 | Experimental groups | ||||||||
---|---|---|---|---|---|---|---|---|---|
 | Naive | Virus control | Sham/sham | Sham/OVA | Virus/nil | Virus/OVA | OVA/sham | Virus+OVA/nil | Virus/OVA IL-4Rα -/- |
Intrapulmonary CD3+ T cells/mm2 | 2.8 (0.8) | 7.2 (0.9) | 3.3 (0.6)# | 8.0 (1.3) | 10.4 (3.2) * | 10.2 (2.2) * | 4.4 (0.9) | 6.6 (0.8) | 4.7 (1.2) |
Intrapulmonary eosinophils/mm2 | 2.7 (0.6) | 3.7 (0.9)# | 1.5 (0.4)### | 3.7 (1.1)# | 3.0 (0.8)# | 6.5 (0.6) *** | 1.1 (0.5)### | 5.7 (0.9) | 0.9 (0.3)### |
Lymphoid aggregates per section§ | 0.0 (0.75) | 2.0 (3.25) * | 0.0 (0.25) | 0.0 (1.25) | 1.0 (4.0) | 1.0 (2.0) | 0.5 (1.0) | 1.0 (1.25) | 2.5 (4.75) ** |
Lamina propria cells/100 μm basement membrane | 19.2 (1.0) | 22.3 (1.1) | 19.6 (1.7)# | 24.0 (1.2) * | 24.8 (1.5) * | 25.1 (1.2) * | 20.0 (1.5) | 22.0 (1.6) | 21.7 (1.0) |
Thickness of subepithelial collagen zone (μm) | 3.2 (0.2) | 4.0 (0.2) | 2.7 (0.2)### | 4.7 (0.2) *** | 4.3 (0.2) ** | 4.8 (0.1) *** | 4.2 (0.2) * | 4.2 (0.2) * | 4.4 (0.4) ** |
Thickness of epithelial cell layer (μm) | 12.5 (0.5) | 12.6 (0.8)# | 12.1 (0.7)## | 16.9 (0.5) *** | 15.1 (0.7) | 16.1 (1.3) * | 14.6 (0.7) | 13.7 (0.9) | 16.2 (0.6) * |
Grade of mucous cell metaplasia§ | 1.0 (1.0) | 3.0 (3.0)* | 0.0 (1.0)## | 2.0 (2.0) | 3.0 (2.0) ** | 3.0 (1.0) ** | 2.0 (2.0) | 1.0 (2.0) | 0.0 (0.0)### |