Figure 6
From: Early-life viral infection and allergen exposure interact to induce an asthmatic phenotype in mice
Th2-biased immunological response. (A) Numbers of CD4+ T cells recovered from disaggregated lung tissue. (B) Numbers of eosinophils in tracheal epithelium. (C) Levels of OVA-specific IgE and IgG1 in serum. (D-F) Levels of expression of mRNA for IL-4, IL-5 and IL-13 by CD4+ T-cells, relative to HPRT. Significant differences compared to virus-infected control animals shown as * = P < 0.05, ** = P < 0.01, *** = P < 0.001; compared to sham-infected, OVA-challenged animals (Sham/OVA) shown as # = P < 0.05, ## = P < 0.01.