Cross-desensitization of NK
receptors after consecutive applications of hHK-1 (3.10
M) and [Sar
] SP (10
M) on human bronchi (
= 5). All combinations of hHK-1 and [Sar9,Met(O2)11] SP were assessed. Experiments were performed in the presence of phosphoramidon (10-6 M). Values are expressed in percentage (mean ± s.e.m.) of maximal contraction obtained with ACh 3 mM. Statistical analysis was performed with two-way ANOVA for repeated measures followed with Bonferroni post-test. ** p < 0.01 and *** p < 0.001 for contraction obtained after the second application versus the first application. (Sar9 = [Sar9,Met(O2)11] SP).