Table 3 Major mast cells mediators, many of which have angiogenic activity
From: The role of the bronchial microvasculature in the airway remodelling in asthma and COPD
Mediators | Histamine, Tryptase, Chymase, Heparine, Carboxypeptidase A, MMP-2, MMP-9 |
|---|---|
Cytokines | IL-3, IL-4, IL-5, IL-6, IL-8, IL-9, IL-10, IL-13, TNFα |
Chemokines | RANTES, Eotaxin, MCP-1, MCP-3, MCP-4, IL-8 |
Growth Factors | VEGF, bFGF, TGFβ, GM-CSF, PDGF, PAF |
Lipid-derived compounds | PGD2, LTB4, LTC4, LTD4, LTE4 |