Inhibition of Sirt1 activity in quercetin-treated mice attenuates querecetin-induced changes in MMP expression and emphysema progression. Elastase/LPS-exposed mice were treated with vehicle or quercetin along with sirtinol or PBS. A and B. Mice treated with quercetin and sirtinol did not show reduced MMP9 or MMP12 mRNA expression. Results represent range of data with median (n = 4-6, *different from all other groups, p≤0.05; ANOVA on ranks). C-E. Sirtinol also inhibited quercetin's effects on elastic recoil (C), compliance (D) and elastance (E). Data represent mean and SEM (n = 4-6, *different from all other groups, p≤0.05; one-way ANOVA). C. Representative of 4-6 animals per group.