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Figure 3 | Respiratory Research

Figure 3

From: Nicotine enhances murine airway contractile responses to kinin receptor agonists via activation of JNK- and PDE4-related intracellular pathways

Figure 3

Effects of neuronal nicotinic receptor antagonists on nicotine-enhanced kinin B 1 and B 2 receptor-mediated contractions. Tracheal segments were cultured for 4 days in presence of vehicle (DMSO, 0.1%) or nicotine (Nic, 10 μM) with/without neuronal nicotinic receptor antagonist MG624 (MG, 100 nM, A, B) or hexamethonium (Hexa, 1 or 10 μM, C-F). Contractions were induced by des-Arg9-bradykinin (D-A-BK; A, C, E) or bradykinin (BK; B, D, F). Each data point is derived from 3-6 experiments and data is presented as mean ± S.E.M. Statistical analysis was performed using two-way ANOVA with Bonferroni's post-test. Nic vs Nic+MG/Hexa (A-D), DMSO vs DMSO+MG/Hexa (A, B, E, F). * P < 0.05; ** P < 0.01; *** P < 0.001.

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